Poster Presentation

Publication

Bold: Me
*Corresponding authors

1.

AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity.

Jumpei Maki, Asami Oshimura, Chihiro Tsukano,* Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, and Kazuhiro Irie*

Chem. Commun. 2022, 58, 6693. 

doi.org/10.1039/D2CC01759H

2.

Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analogue of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation.

Jumpei Maki, Yusuke Hanaki, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, and Kazuhiro Irie*

Biosci. Biotechnol. Biochem. 2023, 87, 1453.

doi.org/10.1093/bbb/zbad128

3.
Convergent Synthesis of Antitumor Aplysiatoxin Derivatives Based on a Combination of Ring-closing and Cross Metathesis.

Mako Aoki, Hiroto Takarada, Jumpei Maki, Takumi Kobayashi, Chihiro Tsukano,* Kazuhiro Irie*
Eur. J. Org. Chem. 2025, 28, e202401074.
doi.org/10.1002/ejoc.202401074

4.
Validation of machine learning-assisted screening of PKC ligands: PKC binding affinity and activation.

Jumpei Maki, Asami Oshimura, Yudai Shiotani, Maki Yamanaka, Sogen Okuda, Ryo C. Yanagita, Shigeru Kitani, Yasuhiro Igarashi, Yutaka Saito, Yasubumi Sakakibara, Chihiro Tsukano,* Kazuhiro Irie
Biosci. Biotechnol. Biochem. 2025, 89, 668.
doi.org/10.1093/bbb/zbaf008

5.
Synthesis of Unnatural Aplysiatoxin Analogs with High Affinity for Protein Kinase C.

Mana Morishita, Kohei Hada, Yusuke Araki, Keisuke Fukaya, Daisuke Urabe, Ryo C. Yanagita, Jumpei Maki, Yusuke Hanaki, Masaki Kita, Kazuhiro Irie, Toshio Nishikawa*
Eur. J. Org. Chem. in press.
doi.org.10.1002/ejoc.202500890

Oral Presentation

○: Presenter

1.
Pacifichem 2021, December 2021, virtual
○Irie, K., Tsukano, C., Maki, J., Oshimura, A., Okuda, S., Gonda, A., Yanagita, R.C., Saito, Y., Sakakibara, Y.
Development of new protein kinase C ligands using a machine learning model

2.

日本農芸化学会 2022年度京都大会，京都（オンライン），2022年3月

○眞木準平, 押村亜沙美, 塚野千尋, 柳田亮, 入江一浩

アロタケタール類のトランスデカリン型単純化アナログの合成と PKC 結合活性

3.

第51回 複素環化学討論会，大阪，2022年9月，口頭発表

○眞木準平, 押村亜沙美, 塚野千尋, 柳田亮, 齋藤裕, 榊原康文, 入江一浩

アロタケタール単純化アナログの設計・合成および PKC 結合活性

4.

日本農芸化学会 2023年度広島大会，広島（オンライン） 2023年3月

○眞木準平, 花木祐輔, 柳田 亮, 菊森将之, 鷲崎彩夏, 塚野千尋, 明里宏文, 入江一浩

Aplysiatoxin 単純化アナログ・10-Me-Aplog-1 のリン酸化体の LRA 活性と薬物動態

5.

第66回 天然有機化合物討論会，京都，2024年9月，口頭発表

○眞木準平，奥田創元，押村亜沙美，塩谷侑大，山中麻希，柳田 亮，木谷 茂，五十嵐康弘，齋藤 裕，榊原康文，塚野千尋，入江一浩

機械学習により選抜された新規PKCリガンド候補化合物の活性評価とアイソザイム選択性を志向した分子設計

Poster Presentation

1.
The 100th Anniversary International Conference (Kyoto univ. Faculty of Agriculture), 2023年11月
○Jumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie

Design, synthesis, and PKC surrogate binding of the simplified analogues of alotaketals